Selected Publications from the Ghosh Lab

Lipsmeier F, Taylor KI, Kilchenmann T, Wolf D, Scotland A, Schjodt-Eriksen J, Cheng WY, Fernandez-Garcia I, Siebourg-Polster J, Jin L, Soto J, Verselis L, Boess F, Koller M, Grundman M, Monsch AU, Postuma RB, Ghosh A, Kremer T, Czech C, Gossens C, Lindemann M. (2018) Evaluation of smartphone-based testing to generate exploratory outcome measures in a phase 1 Parkinson's disease clinical trial Mov Disord. Apr 27. doi: 10.1002/mds.27376

Benekareddy M, Stachniak TJ, Bruns A, Knoflach F, von Kienlin M, Künnecke B, Ghosh A. (2018) Identification of a Corticohabenular Circuit Regulating Socially Directed Behavior Biol Psychiatry 83(7):607-617

Staahl BT, Benekareddy M, Coulon-Bainier C, Banfal AA, Floor SN, Sabo JK, Urnes C, Munares GA, Ghosh A, Doudna JA. (2017) Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes. Nat Biotechnol. 35(5):431-434.

Savas JN, Wang YZ, DeNardo LA, Martinez-Bartolome S, McClatchy DB, Hark TJ, Shanks NF, Cozzolino KA, Lavallée-Adam M, Smukowski SN, Park SK, Kelly JW, Koo EH, Nakagawa T, Masliah E, Ghosh A, Yates JR 3rd. Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology. (2017) Cell Reports. 2017 Nov 28;21(9):2614-2627.

Costa V, Aigner S, Vukcevic M, Sauter E, Behr K, Ebeling M, Dunkley T, Friedlein A, Zoffmann S, Meyer CA, Knoflach F, Lugert S, Patsch C, Fjeldskaar F, Chicha-Gaudimier L, Kiialainen A, Piraino P, Bedoucha M, Graf M, Jessberger S, Ghosh A, Bischofberger J, Jagasia R. (2016) mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis. Cell Reports 15:86-95

de Wit J, Ghosh A. (2016) Specification of synaptic connectivity by cell surface interactions. Nat Rev Neurosci. 17(1):4

Martin EA, Muralidhar S, Wang Z, Cervantes DC, Basu R, Taylor MR, Hunter J, Cutforth T, Wilke SA, Ghosh A, Williams ME. (2015) The intellectual disability gene Kirrel3 regulates target-specific mossy fiber synapse development in the hippocampus. Elife. Nov 17;4

Bourane S, Duan B, Koch SC, Dalet A, Britz O, Garcia-Campmany L, Kim E, Cheng L, Ghosh A, Ma Q, Goulding M. (2015) Gate control of mechanical itch by a subpopulation of spinal cord interneurons. Science 350(6260):550-4

Savas JN, Ribeiro LF, Wierda KD, Wright R, DeNardo-Wilke LA, Rice HC, Chamma I, Wang YZ, Zemla R, Lavallée-Adam M, Vennekens KM, O'Sullivan ML, Antonios JK, Hall EA, Thoumine O, Attie AD, Yates JR 3rd, Ghosh A, de Wit J. (2015) The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors. Neuron 87(4):764-80

Brunner D, Kabitzke P, He D, Cox K, Thiede L, Hanania T, Sabath E, Alexandrov V, Saxe M, Peles E, Mills A, Spooren W, Ghosh A, Feliciano P, Benedetti M, Luo Clayton A, Biemans B. (2015) Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder. PLoS One. 2015 Aug 14;10(8):e0134572.

Stachniak TJ, Ghosh A, Sternson SM (2014) Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus→hindbrain pathway for feeding behavior. Neuron 82:797-808

Savas JN, de Wit J, Comoletti D, Zemia R, Ghosh A, Yates III JR (2014) Ecto-Fc MS identifies ligand-receptor interactions through extracellular domain Fc fusion protein baits and shotgun proteomic analysis. Nature Protocols 9:2061-2074

Naryshkin NA, Weetall M, [multiple authors], Ghosh A, Metzger F (2014) SMN2 splicing modifiers improve motor function and longevitiy in mice with spinal muscular atrophy. Science 345:688-693

De Wit J, Ghosh A (2014) Control of Neural Circuit Formation by Leucine-Rich Repeat Proteins. Trends in Neuroscience 37:539-550

O'Sullivan ML, Martini F, von Daake S, Comoletti D, Ghosh A (2014) LPHN3, a Presynaptic Adhesion-GPCR Implicated in ADHD, Regulates the Strength of Neocortical Layer 2/3 Synaptic Input to Layer 5. Neural Dev 9(1):7. doi: 10.1186/1749-8104-9-7

Cruz-Martín A, El-Danaf RN, Osakada F, Sriram B, Dhande OS, Nguyen PL, Callaway EM, Ghosh A*, Huberman AD*. (2014) A dedicated circuit linking direction selective retinal ganglion cells to primary visual cortex. Nature 507:358-361 (*corresponding authors)

Niewoehner J, Bohrmann B, Collin L, Urich E, Sade H, Maier P, Rueger P, Stracke J, Lau W, Tissot AC, Loetscher H, Ghosh A*, Freskgård P* (2014) Increased brain penetration and potency of a therapeutic antibody using a novel monovalent molecular shuttle. Neuron 81(1):49-60 (*corresponding authors)

Wilke, SA, Raam T, Antonios JK, Bushong EA, Koo EH, Ellisman EH, Ghosh A (2014) Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease. PLOS One 9(1):e84349

Ghosh A, Michalon A, Lindemann L, Fontoura P, Santarelli L (2013) Drug Discovery for Autism Spectrum Disorders: Challenges and Opportunities. Nature Reviews Drug Discovery 12:777-790.

De Wit J, O'Sullivan ML, Savas JN, Yates III JR, Ghosh A. (2013) Unbiased Discovery of Glypican as a Novel Receptor for LRRTM4 in Regulating Excitatory Synapse Development. Neuron 79(4):696-711.

Wilke SA, Antonios JK, Bushong EA, Badkoobehi A, Malek E, Hwang M, Terada M, Ellisman MH, Ghosh A. (2013) Deconstructing complexity: serial blockface electron microscopic analysis of the hippocampal mossy fiber synapse. J Neurosci. 33:507-522.

DeNardo LA, de Wit J, Otto-Hitt S, Ghosh A. (2012) NGL-2 regulates input-specific synapse development in CA1 pyramidal neurons. Neuron 76:762-775.

Sylwestrak, E and Ghosh, A. (2012) Elfn1 regulates target-specific release probability at CA1-interneuron synapses. Science 338:536-540.

Spooren W, Lindemann L, Ghosh A, Santarelli L. (2012) Synapse dysfunction in autism: a molecular medicine approach to drug discovery in neurodevelopmental disorders. Trends Pharmacol Sci. 33:669-684.

Shanks NF Savas JN, Maruo T, Cais O, Hirao A, Oe S, Ghosh A, Noda Y, Greger IH, Yates JR, Nakagawa1 T (2012) Differences in AMPA and Kainate Receptor Interactomes Facilitate Identification of AMPA Receptor Auxiliary Subunit GSG1L, Cell Reports 1:590-598.

Charrier C, Joshi K, Coutinho-Budd J, Kim JE, Lambert N, de Marchena J, Jin WL, Vanderhaeghen P, Ghosh A, Sassa T, Polleux F. (2012). Inhibition of SRGAP2 Function by Its Human-Specific Paralogs Induces Neoteny during Spine Maturation. Cell 149(4):923-935.

O'Sullivan ML, de Wit J, Savas JN, Comoletti D, Otto-Hitt S, Yates JR 3rd, A. Ghosh (2012) FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development. Neuron 73:903-910.

Wilke, SA, Hall, BJ, Antonios, JK, Denardo LA, Otto S, Yuan B, Chen F, Robbins EM, Tiglio K, Williams ME, Qiu Z, Biederer T, A. Ghosh (2012). NeuroD2 regulates the development of hippocampal mossy fiber synapses. Neural Dev 7:9.

Qiu, Z., Sylwestrak, EL, Lieberman, DN, Zhang, Y, Liu, XY, A Ghosh (2012) The Rett Syndrome Protein MeCP2 Regulates Synaptic Scaling. J Neurosci. 32:989-994.

Wang, CC, Held, RG, Chang, S-C, Yang, L, Delpire, E, Ghosh, A, BJ Hall (2011) A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function. Neuron 72: 789-805.

de Wit* J, Hong* W, Luo L, A. Ghosh (2011) Role of Leucine-rich repeat proteins in the development and function of neural circuits. Annual Review of Cell and Develop. Biology 27:697-729. [*equal contribution]

Williams, ME, Wilke, SA, Daggett, A, Davis, E, Otto, S., Ravi, D., Ripley, B., Bushong, EA, Ellisman, MH, Klein, G., A. Ghosh (2011) Cadherin-9 regulates synapse-specific differentiation in the developing hippocampus. Neuron 71:640-655.

Kim, JE, O'Sullivan, M., Sanchez, CA, Hwang, M., Israel, M. Brennand, K., Deerinck, T., Goldstein, LSB, Gage, FH, Ellisman, MH, and A. Ghosh (2011) Investigating Synapse Formation and Function Using Human ES and iPS Cell-derived Neurons. Proc Natl Acad Sci USA 108(7):3005-3010.

Ripley*, B., S. Otto*, Tiglio, K., Williams, M., and A. Ghosh (2011) Regulation of presynaptic stability by AMPA receptor reverse signaling. Proc Natl Acad Sci USA 108(1):367-372. [*equal contribution]

Williams, ME, de Wit, J, and A. Ghosh (2010). Molecular Mechanisms of Synaptic Specificity in Developing Neural Circuits. Neuron 68:9-18.

de Wit, J., Sylwestrak, E., O'Sullivan, M., Otto, S., Tiglio, K., Savas, JN, Yates III, J., Comoletti, D., Taylor, P., A. Ghosh, (2009) LRRTM2 interacts with Neurexin1 and Regulates Excitatory Synapse Formation. Neuron 64:799-806.

Scobie KN, Hall BJ, Wilke SA, Klemenhagen KC, Fujii-Kuriyama Y, Ghosh A, Hen R, Sahay A. (2009) Krüppel-like factor 9 is necessary for late-phase neuronal maturation in the developing dentate gyrus and during adult hippocampal neurogenesis. J Neurosci. 29(31):9875-87.

Qiu, Z. and A. Ghosh (2008) A brief history of neuronal gene expression: regulatory mechanisms and cellular consequences. Neuron 60:451-455. Reprint

Davis, E.K., Zou, Y., and A. Ghosh (2008) Wnts acting through canonical and non-canonical pathways exert opposite effects on hippocampal synapse formation. Neural Development 3:32 Reprint

Qiu, Z. and A. Ghosh (2008) A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. Neuron 60:775-787. Reprint

Yuan, S.H., Qiu, Z. and A. Ghosh (2008). TOX3 regulates calcium-dependent transcription in neurons. Proc Natl Acad Sci USA 24;106(8):2909-14. Reprint

Davis, E. and A. Ghosh (2007). Should I stay or should I go: Wnt signals at the synapse. Cell 130:593-596. Reprint

Wu JI, Lessard J, Olave IA, Qiu Z, Ghosh A, Graef IA, Crabtree GR (2007). Regulation of dendritic development by neuron-specific chromatin remodeling complexes. Neuron 56(1):94-108. Reprint

Hall, BJ, Ripley B, A. Ghosh (2007). NR2B signaling regulates the development of synaptic AMPA receptor current. J Neurosci. 27(49):13446-56. Reprint

Ultanir SK, Kim JE, Hall BJ, Deerinck T, Ellisman M, A. Ghosh (2007). Regulation of spine morphology and spine density by NMDA receptor signaling in vivo. Proc Natl Acad Sci USA 104(49):19553-8. Reprint

Polleux, F., Ince, G. I., and A. Ghosh (2007). Transcriptional regulation of axon guidance and synapse formation. Nature Reviews Neuroscience 8:331-340. Reprint

Ince-Dunn, G., Hall, B.H., Hu, S-C., Ripley, B., Huganir, R.L., Olson, J.M., and A. Ghosh (2006). Regulation of thalamocortical patterning and synaptic maturation by NeuroD2. Neuron (cover) 49:683-695. Reprint

Kashani, A.H., Qiu, Z., Jurata, L., Lee, S.-K., Pfaff, S, Goebbels, S., Nave, K.-A., and A. Ghosh (2006). Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections. J. Neurosci. 26:8398-8408. Reprint

Redmond, L. and A. Ghosh (2005) Regulation of dendritic development by calcium signaling. Cell Calcium 37:411-416. Reprint

Konur, Sila, Ghosh A. (2005). Calcium Signaling and the Control of Dendritic Development. Neuron Vol 46, 401-405. Reprint

Chen, Yachi, Ghosh A, (2005). Regulation of Dendritic Development by Neuronal Activity. J. Neurobiol. 64: 4-10. Reprint

Dijkhuizen A. Paul, Ghosh A, (2005). BDNF Regulates primary dendrite formation in cortical neurons via the P13-kinase and MAP kinase signaling pathways. J. Neurobiol. 62(2):278-288. Reprint

Chen Yachi, Wang Phyllis, Ghosh A, (2005). Regulation of cortical dendrite development by Rap1 signaling. Mol. Cell. Neurosci. 28(2):215-228 Reprint

Song MR, Ghosh A, (2004). FGF2-induced chromatin remodeling regulates CNTF-mediated gene expression and astrocyte differentiation. Nat. Neurosci. 7:229-35. Reprint.

Aizawa H, Hu SC, Bobb K, Balakrishnan K, Ince G, Gurevich I, Cowan M, Ghosh A, (2004). Dendrite development regulated by CREST, a calcium-regulated transcriptional activator. Science 303:197-202. Reprint.

Jefferis GS, Komiyama T, Luo L, (2004). Neuroscience. Calcium and CREST for healthy dendrites. Science 303:179-81. Reprint.

Wong RO, Ghosh A, (2002). Activity-dependent regulation of dendritic growth and patterning. Nat. Rev. Neurosci. 3:803-12. Reprint.

Polleux F, Whitford KL, Dijkhuizen PA, Vitalis T, Ghosh A, (2002). Control of cortical interneuron migration by neurotrophins and PI3-kinase signaling. Development 129:3147-60. Reprint.

Redmond L, Kashani AH, Ghosh A, (2002). Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription. Neuron 34:999-1010. Reprint.

Polleux F, Ghosh A, (2002). The slice overlay assay: a versatile tool to study the influence of extracellular signals on neuronal development. Sci. STKE 2002(136):PL9.

Ghosh, A, (2002). Learning more about NMDA receptor regulation. Science 295:449-451. Reprint.

Whitford KL, Dijkhuizen P, Polleux F, Ghosh A, (2002). Molecular control of cortical dendrite development. Annu. Rev. Neurosci. 25:127-49. Reprint.

Whitford KL, Marillat V, Stein E, Goodman CS, Tessier-Lavigne M, Chedotal A, Ghosh A, (2002). Regulation of cortical dendrite development by Slit-Robo interactions. Neuron 33:47-61. Reprint.

Whitford KL, Ghosh A, (2001). Plexin signaling via Off-track and Rho family GTPases. Neuron 32:1-8. Reprint.

Morrow T, Song MR, Ghosh A, (2001). Sequential specification of neurons and glia by developmentally regulated extracellular factors. Development 128:3585-3594. Reprint.

Redmond L, Ghosh A, (2001). The role of Notch and Rho GTPase signaling in the control of dendritic development. Curr. Opin. Neurobiology 11:111-117. Reprint.

Dickson BJ, Cline H, Polleux F, Ghosh A, (2001). Making connections. Meeting: axon guidance and neural plasticity. EMBO Reports 2:182-186.

Ghosh A, (2000). Dendritic Growth: Don't go says Flamingo. Neuron 28:3-4.

Polleux F, Morrow T, Ghosh A, (2000). Semaphorin 3A is a chemoattractant for cortical apical dendrites. Nature 404:567-573. Reprint.

Redmond L, Oh SR, Hicks C, Weinmaster G, Ghosh A, (2000). Nuclear notch1 signaling and the regulation of dendritic development. Nature Neurosci. 3:30-40. Reprint.

Shieh PB, Ghosh A, (1999). Molecular mechanisms underlying activity-dependent regulation of BDNF expression. J. Neurobiol.41:127-134. Reprint.

Hu SC, Chrivia J, Ghosh A, (1999). Regulation of CBP-mediated transcription by neuronal calcium signaling. Neuron 22:799-808. Reprint.

Polleux F, Giger RJ, Ginty DD, Kolodkin AL, Ghosh A, (1998). Patterning of cortical efferent projections by Semaphorin-Neuropilin interactions. Science 282:1904-1906. Reprint.

Ghosh A, Kolodkin AL, (1998). Specification of Neuronal Connectivity: ETS Marks the Spot. Cell 95:303-306. Reprint.

Shieh PB, Hu SC, Bobb K, Timmusk T, Ghosh A, (1998). Identification of a signaling pathway involved in calcium regulation of BDNF expression. Neuron 20:727-740. Reprint.

Shieh PB, Ghosh A, (1997). Neurotrophins: new roles for a seasoned cast. Current Biology 7:R627-R630. Reprint.

Threadgill R, Bobb K, Ghosh A, (1997). Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42. Neuron 19:625-634. Reprint.

Ghosh A, (1996). Cortical development: With an eye on Neurotrophins. Current Biology 6:130-133. Reprint.

Ghosh A, Greenberg ME, (1995). Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis. Neuron 15:89-103.

Ghosh A, Greenberg ME, (1995). Calcium signaling in neurons: Molecular mechanisms and cellular consequences. Science 268:239-247.

Ghosh A, Carnahan J, Greenberg ME, (1994). Requirement for BDNF in the activity-dependent survival of cortical neurons. Science 263:1618-1623.

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